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SC1 Molecular Mechanisms of Amino Acid Transport in Mosquitoes

07-31-2020 -

Novel public health insecticides with new modes of action are urgently needed to protect the health of human populations in many countries worldwide. This project focuses on the family of cationic amino acid transporters (SLC7) of the yellow fever mosquito, Aedes aegypti, the principal vector of dengue fever, chikungunya, and Zika virus. The mode of action and substrate specificity of five SLC7s will be studied, in order to understand how this class of transporters functions. We will unravel the cellular nutrient signaling cascade downstream of these transceptors (transporters with receptor function) and study how knockout will affect key tissues/organs and mosquito reproduction.